The new HBO sexual drama, Open, has confirmed Michelle Monaghan (Boston Public) for the lead female, Grace, a successful and recently engaged gynecologist. The pilot is from Ryan Murphy (Nip/Tuck and will be co-written with Lauren Gussis (Dexter). The Fox 21 project is about human sexuality, relationships and provocative exploration.

Also on the show is Scott Speedman, who plays Grace’s fiance Jonathan, Wes Bentley (Evan), Anna Torv (Windsor) and Jennifer Jason Leigh (Holly).